The first Study Center of QOU was established in Jenin in 1991 and was affiliated to Nablus Branch. In 1999/2000, the University Council decided to convert the Center to a Branch to serve more than 60 residential compounds in the governorate due to the increasing number of enrolled students. Therefore, the University established the main branch in the northern part of Jenin, and the study center in the southern part of the city.

In 2013, the Study Center was merged into the main branch to become one branch located in the center of Jenin. The number of registered students reached (5500) students in the academic year (2021/2020). Then the University received seven dunums as donation from Qabatya town and it bought another 10 dunums from neighboring lands. The first phase of the construction, which consisted of building the theater and the administrative building, was accomplished in addition to the construction of the second phase, which consisted of building part of the academic building, was also completed.